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Brand Vs. Generic Drug
How do brand name drugs and
generics differ?
When scientists develop a new
drug for the first time, they
give it a generic name reflecting its chemical makeup. Once
FDA approves the drug, the manufacturer markets it with a
brand or trade name which is usually shorter and easier to
remember. A drug company can hold exclusive patent rights to
make a drug for 20 years after its discovery. After that,
any other company can start making generic versions of the
drug.
Are generic drugs safe like
brand name drugs?
Generic drugs work as well as
their brand-name siblings, and often cost significantly
less. This is possible not because of lower quality, but
because research and advertising costs are much less for
generics. Many insurance plans encourage you to accept the
generic version of a drug whenever it's medically safe. Most
states let pharmacists substitute a generic drug when
appropriate and when your doctor approves it.
When shouldn't generics be
substituted for brand name drugs?
Very few drugs have a "narrow
therapeutic index," meaning that a small variation in dose
can cause problems, such as too little effectiveness or too
many side effects. With some drugs, including phenytoin
(brand name Dilantin), carbamazepine (Tegretol), valproic
acid (Depakene), divalproex sodium (Depakote), digoxin (Lanoxin),
warfarin (Coumadin), lithium (Lithobid, Eskalith),
levothyroxine (Synthroid, Levoxyl), and theophylline (Theo-Dur),
you shouldn't switch from brand to generic—or vice
versa—without your doctor's approval and close supervision.
Always consult your doctor, pharmacist, or both before
asking for a substitute.
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